a:5:{s:8:"template";s:12259:"<!DOCTYPE html>
<html lang="en">
<head>
<meta charset="utf-8"/>
<title>{{ keyword }}</title>
<meta content="width=device-width, initial-scale=1.0" name="viewport"/>
<link href="//fonts.googleapis.com/css?family=Lato:300,300italic,400,400italic,700,900%7CYeseva+One:400%7CGentium+Book+Basic:700,700italic&amp;subset=latin,latin,latin" rel="stylesheet" type="text/css"/> 
<style rel="stylesheet" type="text/css">@charset "UTF-8";.has-drop-cap:not(:focus):first-letter{float:left;font-size:8.4em;line-height:.68;font-weight:100;margin:.05em .1em 0 0;text-transform:uppercase;font-style:normal}.wc-block-product-categories__button:not(:disabled):not([aria-disabled=true]):hover{background-color:#fff;color:#191e23;box-shadow:inset 0 0 0 1px #e2e4e7,inset 0 0 0 2px #fff,0 1px 1px rgba(25,30,35,.2)}.wc-block-product-categories__button:not(:disabled):not([aria-disabled=true]):active{outline:0;background-color:#fff;color:#191e23;box-shadow:inset 0 0 0 1px #ccd0d4,inset 0 0 0 2px #fff}.wc-block-product-search .wc-block-product-search__button:not(:disabled):not([aria-disabled=true]):hover{background-color:#fff;color:#191e23;box-shadow:inset 0 0 0 1px #e2e4e7,inset 0 0 0 2px #fff,0 1px 1px rgba(25,30,35,.2)}.wc-block-product-search .wc-block-product-search__button:not(:disabled):not([aria-disabled=true]):active{outline:0;background-color:#fff;color:#191e23;box-shadow:inset 0 0 0 1px #ccd0d4,inset 0 0 0 2px #fff}/ /*! normalize.css v3.0.3 | MIT License | github.com/necolas/normalize.css */html{font-family:sans-serif;-ms-text-size-adjust:100%;-webkit-text-size-adjust:100%}body{margin:0}footer,nav,section{display:block}a{background-color:transparent}a:active,a:hover{outline:0}/*! Source: https://github.com/h5bp/html5-boilerplate/blob/master/src/css/main.css */@media print{*,:after,:before{background:0 0!important;color:#000!important;box-shadow:none!important;text-shadow:none!important}a,a:visited{text-decoration:underline}a[href]:after{content:" (" attr(href) ")"}a[href^="#"]:after{content:""}h3,p{orphans:3;widows:3}h3{page-break-after:avoid}.navbar{display:none}} html{font-size:10px;-webkit-tap-highlight-color:transparent}body{font-family:"Helvetica Neue",Helvetica,Arial,sans-serif;font-size:14px;line-height:1.7142857143;color:#4c4c4c;background-color:#fff}a{color:#337ab7;text-decoration:none}a:focus,a:hover{color:#23527c;text-decoration:underline}a:focus{outline:thin dotted;outline:5px auto -webkit-focus-ring-color;outline-offset:-2px}h3{font-family:inherit;font-weight:500;line-height:1.1;color:inherit}h3{margin-top:23px;margin-bottom:11.5px}h3{font-size:24px}p{margin:0 0 11.5px}ul{margin-top:0;margin-bottom:11.5px}.container{margin-right:auto;margin-left:auto;padding-left:15px;padding-right:15px}.container:after,.container:before{content:" ";display:table}.container:after{clear:both}@media (min-width:768px){.container{width:750px}}@media (min-width:992px){.container{width:970px}}@media (min-width:1200px){.container{width:1170px}}.row{margin-left:-15px;margin-right:-15px}.row:after,.row:before{content:" ";display:table}.row:after{clear:both}.col-sm-12{position:relative;min-height:1px;padding-left:15px;padding-right:15px}@media (min-width:768px){.col-sm-12{float:left}.col-sm-12{width:100%}}.collapse{display:none}.nav:after,.nav:before{content:" ";display:table}.nav:after{clear:both}.nav{margin-bottom:0;padding-left:0;list-style:none}.nav>li,.nav>li>a{position:relative;display:block}.nav>li>a{padding:10px 15px}.nav>li>a:focus,.nav>li>a:hover{text-decoration:none;background-color:#e9e9e9}.navbar{position:relative;min-height:50px;margin-bottom:23px;border:1px solid transparent}.navbar:after,.navbar:before{content:" ";display:table}.navbar:after{clear:both}@media (min-width:992px){.navbar{border-radius:4px}}.navbar-header:after,.navbar-header:before{content:" ";display:table}.navbar-header:after{clear:both}@media (min-width:992px){.navbar-header{float:left}}.navbar-collapse{overflow-x:visible;padding-right:15px;padding-left:15px;border-top:1px solid transparent;box-shadow:inset 0 1px 0 rgba(255,255,255,.1);-webkit-overflow-scrolling:touch}.navbar-collapse:after,.navbar-collapse:before{content:" ";display:table}.navbar-collapse:after{clear:both}@media (min-width:992px){.navbar-collapse{width:auto;border-top:0;box-shadow:none}.navbar-collapse.collapse{display:block!important;height:auto!important;padding-bottom:0;overflow:visible!important}.navbar-static-top .navbar-collapse{padding-left:0;padding-right:0}}.container>.navbar-header{margin-right:-15px;margin-left:-15px}@media (min-width:992px){.container>.navbar-header{margin-right:0;margin-left:0}}.navbar-static-top{z-index:1000;border-width:0 0 1px}@media (min-width:992px){.navbar-static-top{border-radius:0}}.navbar-nav{margin:6.75px -15px}.navbar-nav>li>a{padding-top:10px;padding-bottom:10px;line-height:23px}@media (min-width:992px){.navbar-nav{float:left;margin:0}.navbar-nav>li{float:left}.navbar-nav>li>a{padding-top:13.5px;padding-bottom:13.5px}}@media (min-width:992px){.navbar-right{float:right!important;margin-right:-15px}}@-ms-viewport{width:device-width} body{-webkit-font-smoothing:antialiased}h3{font-weight:700;line-height:1.5em}h3{font-size:18px}a{transition:color .2s}a,a:hover{text-decoration:none}a:active,a:focus{outline:0;text-decoration:none}.text-none{text-transform:none!important}@media (max-width:767px){h3{font-size:18px}}@media (max-width:320px){body{font-size:14px}h3{font-size:16px}}.menu .nav>li>a:focus{outline:0}#content{overflow:hidden;width:100%;transition:opacity .2s}.container{position:relative;z-index:3}.section{position:relative;overflow:hidden}@media (max-width:767px){.container>.navbar-header{margin-right:0;margin-left:0}}.menu .navbar-nav{margin-left:0;margin-right:0}.menu,.menu .nav>li>a{-webkit-transform:translate3d(0,0,0);transform:translate3d(0,0,0)}.menu{margin-bottom:0;width:100%;top:0;left:0;border:0;-webkit-backface-visibility:hidden;transition:background-color .3s,min-height .3s,box-shadow .3s}.menu .container,.menu .nav>li>a{position:relative}.menu .nav>li>a{text-shadow:none;font-style:normal;transition:all .3s;padding-left:20px;padding-right:20px}.menu .nav>li>a:before{content:"";display:block;position:absolute;top:0;left:50%;-ms-transform:translateX(-50%);-webkit-transform:translateX(-50%);transform:translateX(-50%);width:0;opacity:0;transition:background .3s,width .2s}.menu .navbar-collapse{padding-left:0;padding-right:0}@media (min-width:992px){.header-logo-left-menu-right .main-navbar,.header-logo-left-menu-right .menu-container{float:left}.header-logo-left-menu-right .nav-container{float:right}}@media (max-width:991px){.menu .navbar-nav>li>a{padding-top:8px!important;padding-bottom:8px!important}.menu .navbar-nav>li>a:before{display:none}.menu{margin-bottom:0;margin-left:0;margin-right:0}} .sidebar-widget{margin-bottom:36px}.sidebar-header{margin-top:0;position:relative}#footer .sidebar-widget{margin-bottom:24px}#footer .sidebar-widget:last-child{margin-bottom:0}@media (max-width:991px){#footer .sidebar-widget{text-align:left}#footer .sidebar-header:after{left:0;margin-left:0!important}}.element-top-60{margin-top:60px!important}.element-bottom-60{margin-bottom:60px!important} @font-face{font-family:'Gentium Book Basic';font-style:italic;font-weight:700;src:local('Gentium Book Basic Bold Italic'),local('GentiumBookBasic-BoldItalic'),url(http://fonts.gstatic.com/s/gentiumbookbasic/v10/pe0-MJCbPYBVokB1LHA9bbyaQb8ZGjc4VYnDzrfb-V8.ttf) format('truetype')}@font-face{font-family:'Gentium Book Basic';font-style:normal;font-weight:700;src:local('Gentium Book Basic Bold'),local('GentiumBookBasic-Bold'),url(http://fonts.gstatic.com/s/gentiumbookbasic/v10/pe0wMJCbPYBVokB1LHA9bbyaQb8ZGjcw65RvzIfc.ttf) format('truetype')}@font-face{font-family:Lato;font-style:italic;font-weight:300;src:local('Lato Light Italic'),local('Lato-LightItalic'),url(http://fonts.gstatic.com/s/lato/v16/S6u_w4BMUTPHjxsI9w2_Gwfo.ttf) format('truetype')}@font-face{font-family:Lato;font-style:italic;font-weight:400;src:local('Lato Italic'),local('Lato-Italic'),url(http://fonts.gstatic.com/s/lato/v16/S6u8w4BMUTPHjxsAXC-v.ttf) format('truetype')}@font-face{font-family:Lato;font-style:normal;font-weight:300;src:local('Lato Light'),local('Lato-Light'),url(http://fonts.gstatic.com/s/lato/v16/S6u9w4BMUTPHh7USSwiPHA.ttf) format('truetype')}@font-face{font-family:Lato;font-style:normal;font-weight:400;src:local('Lato Regular'),local('Lato-Regular'),url(http://fonts.gstatic.com/s/lato/v16/S6uyw4BMUTPHjx4wWw.ttf) format('truetype')}@font-face{font-family:Lato;font-style:normal;font-weight:700;src:local('Lato Bold'),local('Lato-Bold'),url(http://fonts.gstatic.com/s/lato/v16/S6u9w4BMUTPHh6UVSwiPHA.ttf) format('truetype')}@font-face{font-family:Lato;font-style:normal;font-weight:900;src:local('Lato Black'),local('Lato-Black'),url(http://fonts.gstatic.com/s/lato/v16/S6u9w4BMUTPHh50XSwiPHA.ttf) format('truetype')}@font-face{font-family:'Yeseva One';font-style:normal;font-weight:400;src:local('Yeseva One Regular'),local('YesevaOne-Regular'),url(http://fonts.gstatic.com/s/yesevaone/v14/OpNJno4ck8vc-xYpwWWxli1VXg.ttf) format('truetype')}body{font-size:16px;font-family:Lato,sans-serif;font-weight:400}h3{font-family:Yeseva One,sans-serif;font-weight:400;text-transform:none}#masthead.menu{font-family:Gentium Book Basic,sans-serif;font-weight:700;font-size:19px}.logo-navbar .nav>li>a{padding-top:48px;padding-bottom:48px;line-height:24px}.logo-navbar .nav>li>a:before{margin-bottom:- 22px}.logo-navbar .nav>li>a:hover:before{opacity:1;margin-bottom:- 24px}#masthead.navbar{min-height:120px;background:rgba(0,0,0,.2)!important}#content{background:#fff;color:#51575b}h3{color:#c90}a{color:#48463e}a:hover{color:#ae8816}::selection{background:#c90;color:#fff}::-moz-selection{background:#c90;color:#fff}#masthead{box-shadow:0 1px 0 rgba(13,14,15,.5),0 -1px 0 rgba(13,14,15,.5)}.menu{color:#fff;background:rgba(31,21,21,.87)}.menu a{color:rgba(255,255,255,.8)}.menu a:before{height:4px}.menu .nav>li>a{color:rgba(255,255,255,.8)}.menu .nav>li>a:focus,.menu .nav>li>a:hover{color:#c90;background:0 0}.menu .nav>li>a:focus:before,.menu .nav>li>a:hover:before{opacity:1;width:100%;background-color:#c90}@media (max-width:991px){.menu .navbar-collapse{box-shadow:inset 0 1px 0 rgba(0,0,0,.055)}.menu .nav>li>a{border-radius:0}}.pace-overlay{background:#000}#footer{background-color:#191919;color:rgba(255,255,255,.6)}#footer h3{color:#fff}h3{color:#3b3832!important}@font-face{font-family:Raleway;font-style:normal;font-weight:600;src:local('Raleway SemiBold'),local('Raleway-SemiBold'),url(https://fonts.gstatic.com/s/raleway/v14/1Ptrg8zYS_SKggPNwPIsWqZPBQ.ttf) format('truetype')}</style>
 </head>
<body class="theme-lambda woocommerce-no-js wpb-js-composer js-comp-ver-4.12 vc_responsive">
<div class="pace-overlay"></div>
<div class="menu navbar navbar-static-top header-logo-left-menu-right oxy-mega-menu navbar-not-sticky navbar-mobile-stuck text-none" id="masthead" role="banner">
<div class="container">
<div class="navbar-header">
{{ keyword }}
</div>
<div class="nav-container">
<nav class="collapse navbar-collapse main-navbar logo-navbar navbar-right" role="navigation">
<div class="menu-container"><ul class="nav navbar-nav" id="menu-main"><li class="menu-item menu-item-type-post_type menu-item-object-page menu-item-home menu-item-84" id="menu-item-84"><a href="#">About</a></li>
<li class="menu-item menu-item-type-post_type menu-item-object-page menu-item-1035" id="menu-item-1035"><a href="#">Map</a></li>
<li class="menu-item menu-item-type-post_type menu-item-object-page current_page_parent menu-item-296" id="menu-item-296"><a href="#">Blog</a></li>
<li class="menu-item menu-item-type-post_type menu-item-object-page menu-item-88" id="menu-item-88"><a href="#">Contact</a></li>
</ul></div>
</nav>
</div>
</div>
</div>
<div id="content" role="main">
{{ text }}
<footer id="footer" role="contentinfo">
<section class="section">
<div class="container">
<div class="row element-top-60 element-bottom-60 footer-columns-3">
<div class="col-sm-12">
<div class="sidebar-widget widget_text" id="text-1"><h3 class="sidebar-header">{{ keyword }}</h3> <div class="textwidget"><p></p>
{{ links }}
</div>
</div> </div>
</div>
</div>
</section>
</footer>
</div>
</body>
</html>";s:4:"text";s:10811:"<br>In fact, 75% of the 2 million patients in the US who have IBD are refractory to first line biologic therapy¹. Interestingly, pamoate is a compound previously considered by the Food and Drug Administration as an inactive “salt” component, used to prolong the life of formulations in a wide range of drugs which are currently available on the market (Neubig, 2010). Genetic variation in the gene encoding calpain-10 is associated with type 2 diabetes mellitus. <br> <br>Inactivation of enhanced expression of G(i) proteins by pertussis toxin attenuates the development of high blood pressure in spontaneously hypertensive rats. Toxicol. <br> <br>Ther. This is a nanomolar, potentially competitive antagonist of human GPR35 and also reported to inhibit the effects of both pamoic acid and zaprinast at mouse GPR35 (Zhao et al., 2010). <br> <br>393, 55–60. Li, Y., and Anand-Srivastava, M. B. Commun. Identification of genes related to heart failure using global gene expression profiling of human failing myocardium. Although activation of Gα13 is promising regarding CVD pathology, it is important to note that GPR35 also couples to Gαi/o which has been demonstrated to be up-regulated in the on-set of hypertension in spontaneous hypertensive rats (Anand-Srivastava et al., 1991; Li and Anand-Srivastava, 2002). Evidence now suggests possible links between GPR35 and a range of pathological condi … <br> <br>175, 4458–4464. Jenkins et al. Common variants at five new loci associated with early-onset inflammatory bowel disease. Micromolar concentration of kynurenic acid in rat small intestine. For example, Jenkins et al. Syst. <br> <br>147, S46–S55. 46, 903–912. 4, 840–843. J. Pharmacol. Single nucleotide polymorphisms in the gene encoding G protein-coupled receptor 35 (GPR35) are associated with increased risk of inflammatory bowel disease. Kynureninase is a novel candidate gene for hypertension in spontaneously hypertensive rats.        <br> <br>Further downstream, GPCR activation can be monitored by measuring ligand induced changes in second messenger levels and pathways. Br. Antinociceptive effects and synergistic interaction with morphine of intrathecal metabotropic glutamate receptor 2/3 antagonist in the formalin test of rats. <br> <br>Neurosci. <br> <br> <br>Sharif, I., Crockett, T. R., Kane, K. A., and Wainwright, C. L. (2001). (2010) were unable to generate a response at human GPR35 to kynurenic acid when measuring intracellular [Ca2+], nor were they able to demonstrate GPR35 internalization following transfection of a fluorescently tagged form of human GPR35. Synthetic ligands have proved invaluable in the characterization of GPR35, with moderately potent agonists, and more recently, antagonists, becoming available to facilitate receptor characterization efforts and a small number of in vivo research efforts (Table 1). Online ahead of print. Within the up-regulated genes was GPR35. Pharmacology 82, 245–249. Pubmed Abstract | Pubmed Full Text | CrossRef Full Text. Neuropharmacology 60, 1227–1231. G-protein-dependent pathways either used endogenously by GPR35 (G12/13, Gi/o) or subverted (Gq/11) to allow screening of potential agonists of GPR35 via chimeric and/or promiscuous G-proteins. On the other hand, studies in macrophages carrying the IBD-associated T108M polymorphism in GPR35 result in enhanced metabolic activity compared to the wild-type GPR35, which is the opposite effect compared to GPR35 loss of function (Schneditz et al., 2019; Tsukahara et al., 2017). Interestingly, the co-administration of kynurenic acid and zaprinast did not induce an additive effect on anti-nociception, suggesting that the two ligands were acting via the same pathway (Cosi et al., 2010).                                             Articles. Recently, GPR35 has been implicated in the onset of inflammatory bowel disease (IBD), but its role in physiological and pathological processes in the colon remains undefined. Kynurenic acid triggered adhesion of monocytic cells was diminished by pertussis toxin treatment, and reduced by small hairpin-RNA delivery targeting GPR35, thereby implicating GPR35 as a direct mediator of leukocyte adhesion (Barth et al., 2009). Clipboard, Search History, and several other advanced features are temporarily unavailable. Future studies will focus on characterization of the receptor binding pocket, elucidation of receptor specific and potent ligands, and in vivo research to determine the extent of GPR35 regulation and its subsequent contribution to disease. Trends Pharmacol. The ability of kynurenic acid to activate and internalize human, rat, and mouse orthologs of GPR35 at micromolar concentrations was initially demonstrated by Wang et al. Pharmacol. Here, integrating zebrafish and mouse experimental models, we demonstrate that intestinal Gpr35 expression is microbiota dependent and enhanced upon inflammation. Natl. The majority of SNPs identified by Horikawa and colleagues, were also identified in a GWAS aiming to resolve terminal deletions on chromosome 2q37 associated with Albright hereditary osteodystrophy and mild mental retardation. The stability of the G protein-coupled receptor-beta-arrestin interaction determines the mechanism and functional consequence of ERK activation. <br> <br>COVID-19 is an emerging, rapidly evolving situation. <br> <br>Kynurenic acid has a dual action on AMPA receptor responses. 427, 235–242. Biochem. Kynurenic acid synthesis and kynurenine aminotransferases expression in colon derived normal and cancer cells. 5-Nitro-2-(3-phenylpropylamino)benzoic acid is a GPR35 agonist. <br> <br>			NIH In relation to GPR35, it may be worthwhile to employ techniques to assess JNK activation in neonatal cardiomyocytes given the indirect, yet measurable relation to Gα13 reported here and the hypertrophic response previously reported by Min et al. <br> <br>(2010). Res. Sci. Acad. Interestingly, as with the ligands noted above a number of these compounds also showed marked species selectivity. (2006). Chem. These reports are consistent with previous studies which have demonstrated both vascular defects and embryonic lethality in response to Gα13 deficiency (Offermanns et al., 1997) and others which associate Gα13 with the regulation of morphogenesis and capillary assembly via Rho GTPases in angiogenesis (Connolly et al., 2002). Yoon, M. H., Choi, J., Bae, H. B., Kim, S. J., Chung, S. T., Jeong, S. W., Chung, S. S., Yoo, K. Y., and Jeong, C. Y. Find NCBI SARS-CoV-2 literature, sequence, and clinical content: https://www.ncbi.nlm.nih.gov/sars-cov-2/. However, as with the four SNPs associated with type 2 diabetes, the authors did not comment specifically on the potential contribution of GPR35. Two pathways for lysophosphatidic acid production. 			 |  Immunome Res. Here we demonstrate in zebrafish and mice that expression of Gpr35 is microbiota-dependent and is enhanced upon inflammation. Cell proliferation, mRNA expression, extracellular signal-regulated kinase (ERK) activation, and protein localization were determined by MTT assay, quantitative RT-PCR, western blotting, and immunohistochemistry, respectively. 26, 163–175. <br> <br>Curr. <br> <br>J. Gastroenterol. Maruyama, Y., Nishida, M., Sugimoto, Y., Tanabe, S., Turner, J. H., Kozasa, T., Wada, T., Nagao, T., and Kurose, H. (2002). 			 |  <br> <br>4, 5. Probe Reports from the NIH Molecular Libraries Program [Internet]. 66, 537–544. Res. Tryptophan metabolism via the kynurenine pathway in experimental chronic renal failure. <br> <br>Scand. Using a Ca2+/aequorin assay, this group also demonstrated that kynurenic acid could increase intracellular calcium levels whilst coupling to the chimeric G-proteins Gqo5, Gqi9, and also the pertussis toxin-sensitive Gi/o pathway by employing a [35S]GTPγS binding assay (Wang et al., 2006). Thus, ERK1/2 assays incorporate multiple G-protein signals that converge within the same cell, generating an experimental system that can measure GPCR activation without prior knowledge of G-protein coupling. Principles: extending the utility of [35S]GTP gamma S binding assays. Orthologue selectivity and ligand bias: translating the pharmacology of GPR35. The majority of other currently described GPR35 synthetic ligands (Table 1) have been identified via screens of the Prestwick Chemical Library®, which contains 1120 small molecule drugs with known bioavailability and safety characteristics. 24, 3186–3195. II., Boerwinkle, E., and Kardia, S. L. (2008). 395, 232–237. Nature 391, 177–181. The researchers conclude that the deactivation, as well as an uncontrolled activation, of GPR35 promotes the onset of bowel inflammation. <br> Physiol. e-mail: graeme.milligan@glasgow.ac.uk, Front. G protein-coupled receptors (GPCRs) remain the best studied class of cell surface receptors and the most tractable family of proteins for novel small molecule drug discovery. (2006). 106, 741–747. We identify a GPR35+ colonic macrophage population in mice that is characterized by increased production of pro-inflammatory cytokines, and determine that lysophosphatidic acid (LPA) acts as an endogenous GPR35 ligand to induce Tnf expression. 270, 59–61. In this study, we observed that changing the metabolic synthesis of KA significantly influenced the GPR35 response and signal transduction. Suzuki, N., Hajicek, N., and Kozasa, T. (2009). Nonetheless, a number of groups have begun to elucidate the pharmacology, function, and therapeutic potential of GPR35. Therefore, it might be relevant to suggest that multiple G-protein pathways contribute toward the hypertensive phenotype associated with GPR35. Amino Acids 35, 503–505. Inhibition of N-type calcium channels by activation of GPR35, an orphan receptor, heterologously expressed in rat sympathetic neurons. Kuc, D., Zgrajka, W., Parada-Turska, J., Urbanik-Sypniewska, T., and Turski, W. A. <br> <br>Additionally, GPCR–G-protein fusions and immunoprecipitation of [35S]GTPγS labeled Gα subunits have enabled measurement of activation of Gαq, Gα12/13, or Gαs via modifications of the standard [35S]GTPγS assay (Milligan, 2003). Keywords: GPR35, diabetes, cardiovascular disease, G-proteins, Citation: MacKenzie AE, Lappin JE, Taylor DL, Nicklin SA and Milligan G (2011) GPR35 as a novel therapeutic target. Although GPR35 was identified 13 years ago, initial progress has been slow to elucidate the function and pharmacology of this “orphan” receptor. <br> <br>Clipboard, Search History, and several other advanced features are temporarily unavailable. Yeast assays for G protein-coupled receptors.      Milligan, G. (2003). Pharmacol. 398, 420–425. Marchese, A., Paing, M. M., Temple, B. R., and Trejo, J. <br> <br>Emphasis on kynurenine pathway inhibitors. <br>";s:7:"keyword";s:9:"gpr35 ibd";s:5:"links";s:7630:"<a href='https://crosscurrentcommunications.net/docs/b14002-jontron-official-website'>Jontron Official Website</a>,
<a href='https://crosscurrentcommunications.net/docs/b14002-japanese-male-names'>Japanese Male Names</a>,
<a href='https://crosscurrentcommunications.net/docs/b14002-dotclear-cms'>Dotclear Cms</a>,
<a href='https://crosscurrentcommunications.net/docs/b14002-kill-a-watt-amazon'>Kill A Watt Amazon</a>,
<a href='https://crosscurrentcommunications.net/docs/b14002-pitbull-2020'>Pitbull 2020</a>,
<a href='https://crosscurrentcommunications.net/docs/b14002-duplicator-pro-incremental-backup'>Duplicator Pro Incremental Backup</a>,
<a href='https://crosscurrentcommunications.net/docs/b14002-barcelona-to-tarragona-renfe'>Barcelona To Tarragona Renfe</a>,
<a href='https://crosscurrentcommunications.net/docs/b14002-northern-territory-faunal-emblem'>Northern Territory Faunal Emblem</a>,
<a href='https://crosscurrentcommunications.net/docs/b14002-intensive-reading-strategies'>Intensive Reading Strategies</a>,
<a href='https://crosscurrentcommunications.net/docs/b14002-marietta-diner-menu'>Marietta Diner Menu</a>,
<a href='https://crosscurrentcommunications.net/docs/b14002-arnold-palmer-grandson-golfer'>Arnold Palmer Grandson Golfer</a>,
<a href='https://crosscurrentcommunications.net/docs/b14002-national-saving-rate-formula'>National Saving Rate Formula</a>,
<a href='https://crosscurrentcommunications.net/docs/b14002-mac-mall-rapper'>Mac Mall Rapper</a>,
<a href='https://crosscurrentcommunications.net/docs/b14002-omen-of-death-bird'>Omen Of Death Bird</a>,
<a href='https://crosscurrentcommunications.net/docs/b14002-virtual-piano-sheets-roblox'>Virtual Piano Sheets Roblox</a>,
<a href='https://crosscurrentcommunications.net/docs/b14002-central-park-middlesbrough-email-address'>Central Park Middlesbrough Email Address</a>,
<a href='https://crosscurrentcommunications.net/docs/b14002-output-voltage-calculator'>Output Voltage Calculator</a>,
<a href='https://crosscurrentcommunications.net/docs/b14002-bus-rotorua-to-auckland-airport'>Bus Rotorua To Auckland Airport</a>,
<a href='https://crosscurrentcommunications.net/docs/b14002-compare-industry-super-funds'>Compare Industry Super Funds</a>,
<a href='https://crosscurrentcommunications.net/docs/b14002-teacher%27s-pet-melanie-martinez'>Teacher's Pet Melanie Martinez</a>,
<a href='https://crosscurrentcommunications.net/docs/b14002-song-history'>Song History</a>,
<a href='https://crosscurrentcommunications.net/docs/b14002-undertow-song'>Undertow Song</a>,
<a href='https://crosscurrentcommunications.net/docs/b14002-btu-to-watt-hour'>Btu To Watt Hour</a>,
<a href='https://crosscurrentcommunications.net/docs/b14002-hypalon-rib'>Hypalon Rib</a>,
<a href='https://crosscurrentcommunications.net/docs/b14002-amiodarone-side-effects-elderly'>Amiodarone Side Effects Elderly</a>,
<a href='https://crosscurrentcommunications.net/docs/b14002-recaptcha-not-working'>Recaptcha Not Working</a>,
<a href='https://crosscurrentcommunications.net/docs/b14002-george-strait-love-song-lyrics'>George Strait Love Song Lyrics</a>,
<a href='https://crosscurrentcommunications.net/docs/b14002-poster-on-teachers-day-with-slogan'>Poster On Teachers Day With Slogan</a>,
<a href='https://crosscurrentcommunications.net/docs/b14002-whodini-friends-lyrics'>Whodini Friends Lyrics</a>,
<a href='https://crosscurrentcommunications.net/docs/b14002-shoukry-sarhan-cause-of-death'>Shoukry Sarhan Cause Of Death</a>,
<a href='https://crosscurrentcommunications.net/docs/b14002-curtiss-cook-family'>Curtiss Cook Family</a>,
<a href='https://crosscurrentcommunications.net/docs/b14002-boat-drawing-step-by-step'>Boat Drawing Step By Step</a>,
<a href='https://crosscurrentcommunications.net/docs/b14002-redmine-features-list'>Redmine Features List</a>,
<a href='https://crosscurrentcommunications.net/docs/b14002-georgia-power-apprentice-lineman'>Georgia Power Apprentice Lineman</a>,
<a href='https://crosscurrentcommunications.net/docs/b14002-louis-oosthuizen-driver-length'>Louis Oosthuizen Driver Length</a>,
<a href='https://crosscurrentcommunications.net/docs/b14002-cheap-buffet-near-me'>Cheap Buffet Near Me</a>,
<a href='https://crosscurrentcommunications.net/docs/b14002-tattooed-heart-chords'>Tattooed Heart Chords</a>,
<a href='https://crosscurrentcommunications.net/docs/b14002-southern-university-dancing-dolls-jordan'>Southern University Dancing Dolls Jordan</a>,
<a href='https://crosscurrentcommunications.net/docs/b14002-backchat-app'>Backchat App</a>,
<a href='https://crosscurrentcommunications.net/docs/b14002-how-old-is-star-williams'>How Old Is Star Williams</a>,
<a href='https://crosscurrentcommunications.net/docs/b14002-redirection-error-mobile-friendly-test'>Redirection Error Mobile-friendly Test</a>,
<a href='https://crosscurrentcommunications.net/docs/b14002-sidney-fullmer-height'>Sidney Fullmer Height</a>,
<a href='https://crosscurrentcommunications.net/docs/b14002-aventura-mi-corazoncito-meaning'>Aventura Mi Corazoncito Meaning</a>,
<a href='https://crosscurrentcommunications.net/docs/b14002-standing-in-the-rain-country-song'>Standing In The Rain Country Song</a>,
<a href='https://crosscurrentcommunications.net/docs/b14002-humidity-measurement'>Humidity Measurement</a>,
<a href='https://crosscurrentcommunications.net/docs/b14002-recaptcha-is-not-working-in-contact-form-7'>Recaptcha Is Not Working In Contact Form 7</a>,
<a href='https://crosscurrentcommunications.net/docs/b14002-national-day-uk'>National Day Uk</a>,
<a href='https://crosscurrentcommunications.net/docs/b14002-blackwater-river-kayaking'>Blackwater River Kayaking</a>,
<a href='https://crosscurrentcommunications.net/docs/b14002-rti-pyramid-template'>Rti Pyramid Template</a>,
<a href='https://crosscurrentcommunications.net/docs/b14002-lumen-learning-boundless-biology'>Lumen Learning Boundless Biology</a>,
<a href='https://crosscurrentcommunications.net/docs/b14002-project-eldest-son-iraq'>Project Eldest Son Iraq</a>,
<a href='https://crosscurrentcommunications.net/docs/b14002-what-formula-is-used-to-find-watt-hours'>What Formula Is Used To Find Watt-hours</a>,
<a href='https://crosscurrentcommunications.net/docs/b14002-lockdown-2'>Lockdown 2</a>,
<a href='https://crosscurrentcommunications.net/docs/b14002-3rd-bass-songs'>3rd Bass Songs</a>,
<a href='https://crosscurrentcommunications.net/docs/b14002-stack-on-22-gun-security-cabinet-gcb-1522-ds'>Stack-on 22-gun Security Cabinet Gcb-1522-ds</a>,
<a href='https://crosscurrentcommunications.net/docs/b14002-1-henry-is-equal-to-how-many-ohms'>1 Henry Is Equal To How Many Ohms</a>,
<a href='https://crosscurrentcommunications.net/docs/b14002-house-of-bao-carlsbad'>House Of Bao Carlsbad</a>,
<a href='https://crosscurrentcommunications.net/docs/b14002-twickenham-restaurants-open'>Twickenham Restaurants Open</a>,
<a href='https://crosscurrentcommunications.net/docs/b14002-e-40-thesaurus'>E 40 Thesaurus</a>,
<a href='https://crosscurrentcommunications.net/docs/b14002-young-mc-billboard'>Young Mc Billboard</a>,
<a href='https://crosscurrentcommunications.net/docs/b14002-luis-lacalle-pou-height'>Luis Lacalle Pou Height</a>,
<a href='https://crosscurrentcommunications.net/docs/b14002-bruce-greene-discord'>Bruce Greene Discord</a>,
<a href='https://crosscurrentcommunications.net/docs/b14002-dominic-chianese-2020'>Dominic Chianese 2020</a>,
<a href='https://crosscurrentcommunications.net/docs/b14002-geothermal-energy-advantages-and-disadvantages'>Geothermal Energy Advantages And Disadvantages</a>,
<a href='https://crosscurrentcommunications.net/docs/b14002-bone-restaurant'>Bone Restaurant</a>,
";s:7:"expired";i:-1;}